Margherita Burattini graduated with the highest honors and distinction in classical harp from the G. Rossini Conservatory in Pesaro. In 2022, she completed a Master in baroque and renaissance harp with top marks and distinction at the Civic School of Music C. Abbado under the guidance of Maestro Mara Galassi.

Within the field of baroque music, she has participated in numerous projects in prestigious Italian and European contexts, performing on important stages such as the Teatro Olimpico in Vicenza, Tai Kwun (Hong Kong), Teatro La Fenice (Venice), Teatro Ponchielli (Cremona), NCEM (York, UK), AMUZ (Antwerp, BE), Duomo of Milan, Levi Foundation (Venice), Sforza Castle (Milan), Museum of Musical Instruments (Modena), Teatro G. Verdi (Pordenone). She has taken part in masterclasses with Fabio Bonizzoni, Chiara Granata, Nuria Llopis, and Joachim Held.

In 2018, she was selected as the harpist of the National Baroque Orchestra of the Conservatories. In 2019, she participated in the "Cremona Barocca 2019" residency under the direction of Ottavio Dantone, and in 2020, she took part in the IYAP residency in Belgium (with UnderStories Ensemble) and the Stradella Y Project with Andrea De Carlo. She is the co-founder of the Pyrigon Ensemble, Quartetto Porpora, and Exordium Duo. She is a permanent member of the UnderStories Ensemble (winner of the Most Promising Young Artists award at the York International Young Artists Competition) and the Fattschek Project. She collaborates with Pomo d'Oro, Ensemble Mare Nostrum, Dramatodía, Cremona Antiqua, Orchestra del Teatro La Fenice, Ensemble Locatelli, Madrigalisti Estensi, Accademia dell'Annunciata, Mousiké Association, and the Orchestra Schola S. Rocco. She has recorded for NovaAntiqua Records and Da Vinci Records labels. Lastly, she has performed at significant early music festivals such as Grandezze e Meraviglie, MiTo, Frescobaldi Festival, I Concerti al Cenacolo, Floremus, Urbino Musica Antica Festival, and Milano ArteMusica Festival.

Margherita Burattini specializes in historically informed performance on various harp types, including triple harp (copy of the Barberini harp by luthier Dario Pontiggia), double harp (copy), 18th-century German hooked harp (Haken Harfe, copy of the Bamberger harp by luthier Pepe Weissgerber), single-action pedal harp (original instrument by Louvet from 1778), and gothic harp (copy, by luthier Daniele Poli).